16 th Century-European settlers and the African slave trade import smallpox into:.15 th Century-Portugal occupies part of western Africa, bringing smallpox.11 th Century-Crusades further spread smallpox in Europe.7 th Century-Arab expansion spreads smallpox into northern Africa, Spain, and Portugal.
6 th Century-Increased trade with China and Korea brings smallpox to Japan.Expanding trade routes over the centuries also led to the spread of the disease. Historians trace the global spread of smallpox to the growth of civilizations and exploration. Early written descriptions also appeared in India in the 7 th century and in Asia Minor in the 10 th century. The earliest written description of a disease like smallpox appeared in China in the 4 th century CE (Common Era). The finding of smallpox-like rashes on Egyptian mummies suggests that smallpox has existed for at least 3,000 years.
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